Sample recipe for isopropyl myristate blow dry lotion phase a weight % for 100 g 3. Isopropyl myristate should be used with caution as combining it with some toxic materials will cause the. The top countries of suppliers are brazil, china, and malaysia, from which the percentage of isopropyl myristate supply is 2%, 81%, and 6% respectively. Low viscosity fluid nongreasy emollient, tolerates wide ph range, compatible with most surfactants. Isopropyl myristate is defined as a synthetic oil that is popularly used in both the cosmetics industry as well as the pharmaceutical industry.
Therefore, isopropyl myristate is used as a solubilizing, spreading, and penetrat. Paraben is also negative in other predictive assays. Sigmaaldrich offers a number of isopropyl myristate products. Isopropyl myristate is a synthetic oil used as an emollient, thickening agent, or lubricant in beauty products. Isopropyl myristate recommended for aimed rather than routine. Firstaid measures general advice if symptoms persist, call a physician. Steritest ez system sterility testing of products to be diluted in isopropyl myristate filtration is the pharmacopoeia method of choice for sterility testing. Therefore, isopropyl myristate is used as a solubilizing, spreading, and penetrating agent in anhydrous skin lubricating lotions with high lanolin content.
Investigation of fatty acid esters to replace isopropyl. So isopropyl myristate is in the only product with 0. The dvalues of the solvents tested isopropyl myristate, ethyl laurate, ethyl myristate and isopropyl palmitate are summarized in table 2. If you have purchased a new product you should test it on a small skin area to see if you get a reaction before using the product on larger skin areas. Isopropyl myristate definition of isopropyl myristate by. Airol was the only one that didnt have it and its permanently discontinued. Often, apparent false negatives may be the result of poor quality test conduct, e. Isopropyl myristate recommended for aimed rather than. Yes, using a tissue moistened with tapwater scoring system. Effectiveness of isopropyl myristatecyclomethicone d5.
Information derived from sensitization test methods. Isopropyl myristate ipm, a commonly used penetration enhancer, can act as a plasticizer on durotak 872287. Based upon the safety test data on chemically similar isopropyl esters that is summarized in. Despite its popularity with manufacturers, some side effects have been reported. The plasticization effect caused an enhancement of drug release, an increase in the tack and a decrease in the shearadhesion of the transdermal patch. It is used as a treatment for head lice, in tick and flea products for pets, as a solvent in perfumes, and in cosmetics and topical medicines where good absorption through the skin is desired. A human patch test is available to evaluate the skin sensitising potential of octyl octanoate cas 2306889. In cosmetic manufacturing this ingredient is used to give the finished product a slicker, smoother feel rather than an oily one inci name. Isopropyl myristate is the nonaqueous component of the twophase mouthwash, dentyl ph, where it removes bacteria from the oral cavity. Test is left without refrigeration for more than 4 hours, it may no longer be effective and should be discarded. Viscous products, such as creams and ointments, can be difficult to filter and are normally diluted in a sterile solvent, such as isopropyl myristate ipm. Thus, the use of isopropyl myristate in the sterility test of ointments can produce falsenegative results and cause health problems for some users of such a pharmaceutical preparation.
Final report on the safety assessment of myristyl myristate and. Isopropyl hexadecanoate is used as a food additive. Human studies with isopropyl myristate indicated that it was not a human skin irritant. Eye contact rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes. Final report of the amended safety assessment of myristic acid and. Further, isopropyl myristate is valued for its ability to improve the overall texture of products with high oil content. Isopropyl myristate is an effective agent for solubilizing lanolin. Isopropyl myristatecyclomethicone d5, is a topical formulation containing 5050 ww isopropyl myristatedecamethylcyclopentasiloxane. Isopropyl myristate, the ester of myristic acid and isopropyl alcohol, is also used in topical medications.
Isopropyl myristate is a polar emollient and is used in cosmetic and topical medicinal preparations where good absorption into the skin is desired. It has been attacked by scaremongers either from ignorance or more likely from a cynical desire to sell inferior products at high prices. Steritest ez system sterility testing of products to be. Isopropyl myristate ipm is considered a very weak sensitizer. Its used in cosmetic and topical medicinal preparations. Patient information sheet isopropyl myristate i003 your patch testing results indicate that you have a contact allergy to isopropyl myristate.
It is generally safe, although some people with skin conditions may wish to avoid products containing. A primary dermal irritation study was performed with isopropyl laurate cas 102333 according to oecd guideline 404 dufour, 1991. Isopropyl myristate, nf is an emollient ester of low viscosity used to reduce the greasiness of emulsions. In cosmetics and personal care products, isopropyl myristate functions as a binder, and skinconditioning agent a emollient. Ester of isopropyl alcohol and myristic acid vegetablederived. The study has failed to detect any sensitizing potential. Jun 08, 2011 isopropyl myristate is perfectly safe as a cosmetic ingredient and there are no issues with it as far as end users are concerned. Patch test products sigmaaldrich offers a number of isopropyl myristate products.
Find patient medical information for isopropyl myristate bulk on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. In addition, it is also used to help solubilise actives such as sunscreens, vitamins and perfumes into a base. Isopropyl palmitate is a fatty acid ester obtained by the formal condensation of carboxy group of palmitic acid with propan2ol. Its a level 5 comedogenic ingredient and its the only 0. Isopropyl myristate in mumbai, maharashtra get latest price. Final report on the safety assessment of myristyl myristate. Products with lots of oil can be amazingly beneficial for the skin, but the greasy feel can be a turnoff for many consumers. Properties creamy, conditioning emulsion gives enhanced curl control and hair manageability during the blow drying step.
Isopropyl myristate is often called out as being a particularly bad poreclogging ingredient. Isopropyl myristate was minimally irritating to the rabbits eye, and was not a skin sensitizer in studies with guinea pigs. Patch testing with standard series identifies 7080% of the responsible. Isopropyl myristate is the ester of isopropyl alcohol and myristic acid. Isopropyl myristate, with the chemical formula ch 3 ch 2 12 cooch ch 3 2 4, is an ester of myristic acid, an essential fatty acid derived from palm kernel oil and isopropyl alcohol. Patch test products test cannot be delivered on weekends, mondays or holidays. Isopropyl myristate is perfectly safe as a cosmetic ingredient and there are no issues with it as far as end users are concerned. Acute oral and dermal toxicity tests indicated that myristyl myristate is.
Isopropyl myristate is a light, colorless, oily liquid. It is manufactured through the condensation of isopropyl alcohol and mystic acid. Isopropyl myristate is also used in flea and tick products for pets. Isopropyl myristate ipm has produced slight irritation of human skin, mild irritation of the rabbit eye and moderate irritation of rabbit skin. However, the latest editions of the pharmacopoeias still recommend the usage of isopropyl myristate as a solvent for ointments in sterility tests 8, 9, 10. Sample recipe for isopropyl myristate making cosmetics. This is a valuable attribute, as isopropyl myristate can help other skin healing chemicals to penetrate more deeply. Isopropyl myristate cyclomethicone d5, is a topical formulation containing 5050 ww isopropyl myristate decamethylcyclopentasiloxane.
Composed of of isopropyl alcohol a propane derivative and myristic acid a naturallyoccurring fatty acid, isopropyl myristate is a popular cosmetic and pharmaceutical ingredient. Isopropyl myristate i003 your patch testing results indicate that you have a contact allergy to isopropyl myristate. Isopropyl myristate can be used to dilute aroma chemicals. After 2 years of patch testing, the results obtained with these series were presented, based on data of the information network of departments of dermatology ivdk.
Spectrum chemical nf products are manufactured, packaged and stored under current good manufacturing practices cgmp per 21cfr part 211 in fda registered and inspected facilities. There was a statistically significant difference among the dvalues of isopropyl palmitate 171. It is also used as a pesticide against head lice which works. A wide variety of isopropyl myristate options are available to you, there are 360 suppliers who sells isopropyl myristate on, mainly located in asia. According to the criteria for irritancy and corrosiveness on the skin, off. Effect of isopropyl myristate on the viscoelasticity and drug. Cas 102333, isopropyl myristate cas 110270, isopropyl palmitate cas 142916, and butyl stearate cas 123955. It is important that you familiarize yourself with this chemical and. Other local effects have included nasal and lung irritation during inhalation of aerosols in monkeys and rats, acne development after application to rabbit skin, and increased permeability of human.
Great question, i responded, you should always check the ingredient list in your products. Isopropyl myristate is being studied as a skin enhancer. Isopropyl myristate revision date 24jan2018 component casno weight % isopropyl myristate 110270 95 4. Journal of cosmetology and trichology, november 2015, epublication.
Isopropyl myristate is also used in the removal process of prosthetic makeup. Isopropyl myristate is found in several everyday beauty products and is generally considered safe for consumer use. Its also perfect as a perfume diluent in place of other oils or alcohol. Isopropyl myristate, nf 110270 is145 spectrum chemical. In limited studies, isopropyl myristate was not carcinogenic on the skin of mice, but a mixture of isopropyl myristate and isopropyl alcohol significantly accelerated the carcinogenic activity of benzoapyrene on the skin. Lastly, isopropyl myristate is also believed to have strong skin penetrating properties. Ethyl laurate, with the lowest dvalue, was the solvent with the highest toxicity against p. Find out more about isopropyl myristate, all the commercially available products, formulation examples and other related technical info. It is widely used as a nontoxic alternative for the control of head lice, as an emollient, and a lubricant. It is important that you familiarize yourself with this chemical and take steps to avoid coming in contact with it. Effect of isopropyl myristate on the viscoelasticity and drug release of a druginadhesive transdermal patch containing blonanserineffect of isopropyl myristate on the viscoelasticity and drug release of a druginadhesive transdermal patch containing blonanserinretain. In each case a 48 hr challenge application was given 3 wk later.
The patch test guidelines provided from icdrg and dkg were followed. It is most often used an an additive in aftershaves, shampoos, bath. Isopropyl myristate is a compound derived from isopropyl alcohol and myristic acid. This allnatural ester is used to empart a dry yet moisturising feel to skin creams.
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